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KMID : 0043319980210040445
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Archives of Pharmacal Research
1998 Volume.21 No. 4 p.445 ~ p.451
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Synthesis and Biological Activity of 5-hydroxy-4-quinolones and 5-methoxy-4-quinolones as Truncated Acridones
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Chun Moon-Woo
Kay Kim Olmstead
Choi Yong-Seok
Lee Chong-Ock
Lee Chong-Kyu
Kim Joong-Hyup
Lee Jee-Woo
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Abstract
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A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiheroes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (=17.7 for HL60) which was greater than that of acronycine. However, these compounds didn’t show any significant antiheroes or antituberculosis activity.
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KEYWORD
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Acridone, 5-Hydroxy-4-quinolone, 5-Methoxy-4-quinolone, Antitumor activity, Antiherpes activity, Antituberculosis activity
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